Nisanth R

• Conduct in-process Quality Assurance activities during the dispensing of raw materials from the Stores Department.
• Monitor and oversee production activities for both Skin Care and Hair Care products, ensuring compliance with established quality standards.
• Compile and maintain Batch Manufacturing Records (BMR) and Batch Packaging Records (BPR) documents, ensuring accuracy and completeness.
• Review BPR documents for completeness, accuracy, and compliance with standard operating procedures (SOPs) and regulatory requirements.
• Perform deviation analysis and root cause analysis for any discrepancies or non-compliance identified during production.
• Lead Corrective and Preventive Action (CAPA) implementation to address identified deviations and prevent reoccurrence.
• Collaborate closely with cross-functional teams including Production, Quality Control, and Regulatory Affairs to drive continuous improvement in product quality and compliance.

• Led equipment and area qualification efforts in a sterile manufacturing unit, ensuring compliance with industry standards and regulatory requirements.
• Conducted Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ) activities for critical systems including HVAC, Incubator, and Steam Sterilizer, collaborating closely with vendors.
• Reviewed and analyzed IQ and OQ validation documents, verifying data against predetermined acceptance criteria.
• Prepared and executed Validation (PQ) Protocols, culminating in the generation of comprehensive final reports.
• Developed PQ and Requalification (REQ) documents in adherence to Current Good Manufacturing Practices (CGMP) guidelines.
• Conducted In-Process Quality Assurance (IPQA) for filling, vial washing, media preparation, and dispensing activities, ensuring strict adherence to Standard Operating Procedures (SOPs) and CGMP guidelines.
• Demonstrated proficiency in limited CAPA (Corrective and Preventive Action) processes, effectively addressing non-conformances and driving continuous improvement.
• Applied knowledge of Change Control and Deviation handling procedures to maintain compliance and uphold product quality standards.

To assess the free radical scavenging capacity of Piper betle leaf extract in three different solvents:

• Preparing Piper betle leaf extract in three different solvents, Ethanol, Acetone and water.

• DPPH free radical scavenging assay

• ABTS radical scavenging activity

To determine the in vitro anti-inflammatory activity of Piper betle leaf extract:

• Inhibition of albumin denaturation

• Proteinase inhibitory activity

• Heat induced hemolysis

assay

Impact

• Assessed the free radical scavenging capacity of Piper betle leaf extract
• Determined the in vitro anti-inflammatory activity of Piper betle leaf extract
• Evaluated free radical scavenging activity of Piper betle leaf extract using DPPH free radical scavenging assay and ABTS radical scavenging activity
• Investigated proteinase inhibitory activity and heat induced hemolysis assay to determine the anti-inflammatory activity of Piper betle leaf extract

Work:

• Investigate the inhibitory effect of methanol extract of Alpinia purpurata stem on the growth of struvite crystals
• Employ single diffusion gel growth technique to grow the crystals
• Characterize the grown crystals via Fourier Transform Infrared Spectroscopy (FTIR) and Powder X-Ray diffraction (XRD) methods
• Increase the concentration of methanol extract of Alpinia purpurata stem to observe the effect on weight of struvite crystals
• Harvest crystals and characterize them via Fourier Transform Infrared Spectroscopy (FTIR) and Powder X-Ray Diffraction technique (XRD)
• Verify if Alpinia purpurata stem has the potential to inhibit the formation of struvite crystals
• Check nucleation rate of struvite crystals when using methanol extract of Alpinia purpurata stem

Impact:

• Investigate the inhibitory effect of methanol extract of Alpinia purpurata stem on the growth of struvite crystals
• Crystals harvested from the struvite characterized by Fourier Transform Infrared Spectroscopy (FTIR) to confirm functional groups
• Powder X-Ray Diffraction technique (XRD) analysis confirm crystalline phases of struvite crystals
• Increase in concentration of methanol extract reduce weight of formed crystals from 2.87 g to 0.33 g in struvite crystals
• Alpinia purpurata stem has potential to inhibit formation of struvite crystals
• Using methanol extract of Alpinia purpurata stem can promote formation of ammonium magnesium phosphate hexahydrate crystals and reduce nucleation rate of struvite crystals

Work List:

• Develop toothache product
• Create tooth paste
• Create mouth wash
• Create tooth powder
• Develop bio insecticide
• Extract Acmella oleracea flower extract
• Blend Acmella oleracea flower powder with other ingredients

Impact:

• Improved dental health through toothache product
• Reduced insect damage from bio insecticide

Two days virtual workshop on "Career development through

entrepreneurship" organized by Department of Chemical Engineering, held in Kalasalingam academy of research and development, June 12 & 13, 2020

To investigate the inhibitory effect of methanol extract of Alpinia purpurata stem on the growth of struvite crystals. Struvite crystals were grown by the single diffusion gel growth technique and the inhibitory effect of methanol extractsrite a few sentences about the publication